BOSTON -- Dustin Pedroia spent the first month of the season just one home run shy of 100 in his career. Pedroia reached the milestone with a little panache, hitting a grand slam in the sixth inning and propelling the Boston Red Sox to a 7-1 win over the Oakland Athletics on Friday night. "I was pretty excited to hit a home run. Its been a while," said Pedroia, who had gone 160 at-bats without one. The skid ended when the Red Sox truly needed it, clinging to a 2-1 lead on a night when both clubs were failing to drive in runs. Pedroia drove an 0-2 pitch out to left field in the sixth inning for his second career grand slam and first homer since Sept. 17. "Honestly, I was just trying to drive one run in," Pedroia said. "As a team, weve been scuffling a little bit with guys on." The grand slam put Boston up 6-1 and the cushion was plenty for Clay Buchholz (2-2), who shut down the team with the top record in the American League. Buchholz pitched 6 1-3 innings, allowing one run on three hits and striking out five. He walked three and got himself out of several jams as the As left five on base and were 0-for-7 with runners in scoring position against Buchholz. "We hit some balls hard. We hit a lot of balls hard, actually -- right at people and then didnt get some hits when we did have some guys on base," Oakland manager Bob Melvin said. John Jaso scored Oaklands only run, coming in on a wild pitch after leading off the third with a triple. Boston was having its own struggles with runners on before Pedroia came through in the sixth off of reliever Ryan Cook. Xander Bogaerts and A.J. Pierzynski started the sixth with back-to-back singles off Dan Otero, who began the inning. Otero struck out Will Middlebrooks, then walked Bradley to load the bases with one out. Cook relieved Otero and got Pedroia down 0-2, before he cleared the bases with a shot that just cleared the Green Monster. As manager Bob Melvin challenged whether the ball cleared the yellow line before a fan touched it and lost the appeal. The milestone homer put him in elite Red Sox company as only the second player in franchise history with 100 home runs and 100 stolen bases. Pedroia, who stole his 121st career base in the first inning, joins Carl Yastrzemski (452 home runs, 168 steals). "They told me that after the game. Thats crazy," Pedroia said. "I guess Im getting old. But just having your name anywhere said with his is an accomplishment." Boston hadnt scored since getting a pair of runs in the second inning off starter Dan Straily (1-2). Grady Sizemore led off with a double and scored on Pierzynskis single with one out. Jackie Bradley Jr. added a two-out double to drive in Pierzynski and Boston led 2-0. Straily pitched 4 1-3 innings, allowing two runs on four hits. He struck out three and walked three. "I felt like every single time, every batter I was behind 2-0. Thats just not the way to pitch," Straily said. "Its just a frustrating day." Bradley ended a potential rally for the As in the eighth with a leaping catch at the centre field wall, then hitting Pedroia with a strong relay throw. Pedroia threw to Mike Napoli as Josh Donaldson scrambled to get back after rounding second before seeing Bradley make the catch. Notes: The series continues Saturday afternoon with Boston LHP Jon Lester (2-4) scheduled to face Oakland lefty Tommy Milone (0-2). .. Oakland played its first game in May after tying the franchise record for wins in April at 18-9. ... Buchholz allowed 12 runs on 20 hits over 6 2-3 innings in his first two starts at Fenway Park this season. ... Boston rookie SS Xander Bogaerts has reached safely in 14 straight games. ... Boston C A.J. Pierzynski was played his 1,700th career game behind the plate. ... Pedroia could catch Yastrzemskis steal total of 168, but Yazs 452 homers are probably out of reach for Bostons pesky second baseman. 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San Diego trailed by 21 points at halftime and by 14 in the fourth quarter before Rivers touchdown passes to Antonio Gates and Malcom Floyd, the last one coming with 29 seconds left on the clock. Weddle, the veteran safety, stripped wide receiver Quinton Patton on a 20-yard end-around -- just San Franciscos second play in overtime -- and Novak split the uprights for the win. An unbelievable finish, said Chargers coach Mike McCoy. We had about as bad a first half as we can possible play. Rivers passed for 356 yards with four touchdowns and San Diego (9-6) overcame his three interceptions, including two that led to 14 San Francisco points in the first half. The playoff-hopeful Chargers stopped a two-game losing streak, winning without injured stars Ryan Mathews and Keenan Allen. Shoot, said Rivers, we just got going. We found a little rhythm and finished it off. Despite 355 rushing yards, the 49ers (7-8) suffered their fourth straight loss, guaranteeing them their first non-winning season under Jim Harbaugh. As a team we didnt finish it, said Harbaugh. The guys fought but San Diego did a heck of a job. It was a tremendous comeback. Colin Kaepernick had the second-longest touchdown run by a quarterback in NFL history, a 90-yarder late in the third quarter that restored San Franciscos 14-point lead. It came two just two plays after his fumble was recovered in the end zone by Corey Liuget for a San Diego touchdown. Kaepernick passed for 114 yards with a touchdown to Bruce Ellington and rushed for 151 on seven carries. Frank Gore added 158 yards on 26 rushes, including a 52-yard touchdown run less than two minutes into the game. We did a lot of things well. We just had three turnovers. Thats the difference in the game, said Kaepernick. We have a fumble on the goal line, a fumble that ends in a touchdown and a fumble in overtime. Thats at least a 14-point swing. Rivers has 252 career touchdowns passes, moving within two of Hall of Famer Dan Fouts franchise record. No. 250 was a 1-yard throw to Gates early in the third quarter. San Franciscos Vernon Davis had a 63-yard touchdown catch called back after that because of two penalties, and things got worse for the 49ers when Ricardo Mathews hit Kaepernick, forcing the fumble that Liuget recovered to get the Chargers within 28-21. But the nimble Niners quarterback slipped out of a closing pocket two plays after the kickofff and juked Weddle down the field on his 90-yard touchdown run -- second in NFL history only to Terrelle Pryors 93-yard score for Oakland against Pittsburgh on Oct.dddddddddddd 27, 2013. The 49ers didnt capitalize on Rivers third interception, punting early in the fourth quarter, and the Chargers later pulled within 35-28 on Gates second touchdown catch of the game, a 21-yarder with 5:15 remaining. Gates 99th career touchdown reception tied Hall of Famer Don Hutson for ninth place all-time. Eddie Royal made a diving 17-yard catch on fourth down with a defender on his back, keeping San Diegos game-tying drive alive. Rookie Dontrelle Inman did the same with a 17-yard grab on 4th-and-10, leading to Rivers 11-yard throw to Floyd in between two defenders in the end zone. Kaepernick had a 20-yard scramble on San Franciscos final drive in regulation but Phil Dawson was way short and right on a 60-yard field goal attempt. The 49ers end the season at home next Sunday against Arizona in what could be their last game under Harbaugh, who likely wont remain their coach after this season. Harbaugh, who is 43-19 with the 49ers, has reportedly been offered the head coaching job at Michigan, his alma mater. Theres not much to say except keep fighting and get our last regular-season win, the coach said. Gores bruising 52-yard effort 1:48 into the game was his longest touchdown run in more than five years. The 49ers were close to scoring again on their second possession, but fullback Bruce Miller fumbled at the San Diego 2-yard line when safety Marcus Gilchrist got his helmet on the ball. The Chargers gave it back when Rivers was intercepted by Perrish Cox at the San Francisco 33 and the 49ers scored on Kaepernicks 8-yard touchdown pass to a wide-open Ellington early in the second quarter. On the ensuing Chargers possession, Antoine Bethea stepped in front of Rivers pass over the middle and took the interception back 49 yards without being touched to make it 21-0. Rivers floated a 15-yard touchdown pass to Royal to get the Chargers on the board, but the 49ers marched back down the field to restore their 21-point lead on Ellingtons 1-yard run with six seconds remaining in the first half. Game Notes Royal had 10 catches for 94 yards and Gates added seven for 92. Inman made his first seven NFL receptions for 79 yards ... The banged-up Chargers were without running back Mathews (ankle) for the second straight game because of an ankle injury. Leading receiver Allen sat because of a broken collarbone and injured ankle ... San Diego finishes the regular season next Sunday in Kansas City ... The Chargers have won four in a row against the 49ers dating back to 2002 and lead the regular-season series 7-6 ...49ers safety Eric Reid left the game with a concussion. ' ' '